back Back

New machine and deep learning method identifies Alzheimer’s disease biomarkers and potential targets

Mar. 29, 2023.
1 min. read Interactions

New AI-based Alzheimer's research combines genetic and feature-selection methods

About the Writer

Lewis Farrell

26.68268 MPXR

Highly curious about things that increase my awareness, expand my perception, and make me open to being a better person.

Alzheimer’s disease (AD), the most common cause of dementia and impaired cognitive function, still has no effective treatment, according to researchers. So research is centered on identifying AD biomarkers and targets.

Now, scientists at King Abdullah University of Science and Technology in Saudi Arabia have created a computational method that identifies AD biomarkers and targets. It combines multiple “hub gene” ranking methods and “feature selection” methods with machine learning and deep learning.To identify hub genes and gene subsets, the researchers used three AD gene expression datasets using six ranking algorithms and two feature-selection methods.

The researchers then created machine learning and deep learning models to identify the gene subset that best distinguished Alzheimer’s disease samples from healthy controls. They found that feature selection methods outperformed hub gene sets in terms of prediction performance and that the five genes identified by both feature selection methods had an “AUC” of 0.979.

Based on a literature review, the researchers further showed that 70% of the upregulated hub genes (among the 28 overlapping hub genes) were AD targets, with six miRNA and one transcription factor associated with the upregulated hub genes. According to the researchers, overlapping upregulated hub genes can narrow the search space for potential novel targets.

Source: Nature Scientific Reports (open-access)
Images: MidJourney, Prompts by Lewis Farrell

Interesting story? Please click on the 👍 button below!

Let us know your thoughts! Sign up for a Mindplex account now, join our Telegram, or follow us on Twitter

Comment on this content

0 Comments

0 thoughts on “New machine and deep learning method identifies Alzheimer’s disease biomarkers and potential targets

Like
Dislike
Share

0

Comments
Reactions
💯 💘 😍 🎉 👏
🟨 😴 😡 🤮 💩

Here is where you pick your favorite article of the month. An article that collected the highest number of picks is dubbed "People's Choice". Our editors have their pick, and so do you. Read some of our other articles before you decide and click this button; you can only select one article every month.

People's Choice
Bookmarks